TOP FEMA 4774 SECRETS

We not too long ago noted the event of a novel inhibitor of Rho-mediated gene transcription (1, CCG-203971) that is efficacious in numerous animal versions of acute fibrosis, which includes scleroderma, when supplied intraperitoneally. The modest in vivo potency and very poor pharmacokinetics (PK) of this lead, however, enable it to be unsuitable f